Biography: While she was still a child, her family moved to the United States, living in states such as Massachusetts, Virginia, and Ohio before settling in Las Vegas, Nevada. At 18, she began her exotic dancing career. While working in a Las Vegas dance club, she became intrigued by adult films.
After moving to Los Angeles, California, she immediately began her career in hardcore pornographic films in September 2002. Although she was pursued by other adult film companies, including Vivid Entertainment, Lei became a "Wicked Girl" contract performer for Wicked Pictures in 2003. One of Wicked's performers did not show up for a film shoot and Lei took that actress' role; this performance impressed the company's executives into offering her a contract. As a Wicked Girl, she is said to have worked under the tutelage of Wicked Pictures contract director Michael Raven.
Outside of her adult film work, she used to host a radio show on KSEX, Me So Horny With Keylani Lei, has made an appearance on the Howard Stern radio show, and makes appearances on Playboy TV.
On the business front, Lei previously had an official website, kaylanilei.com, which is now offline. She also inked a deal with California Exotic Novelties for her own line of sex toys.
After meeting in December 2005, Lei began dating Byron Kelleher, a New Zealand rugby union halfback. However in June 2006, The Sunday News reported that the two had split up.